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Recently, single-cell (sc) RNA sequence (RNA-seq) analyses of immune cells from brain samples of an AD model (5XFAD) identified microglial clusters named disease-associated microglia (DAM), which appear under neurodegenerative conditions 21

McCann MR, la Rosa MVGD, Rosania GR, Stringer KA

Efficacy of Alpha-lipoic acid against cadmium toxicity on metal ion and oxidative imbalance, and expression of metallothionein and antioxidant genes in rabbit brain

The EU update affects a section on the permission to import or manufacture a medical device that does not have a predicate device

However, most published studies primarily focus on the interrelationships between ferroptosis, iron metabolism, lipid peroxidation, and amino acid antioxidant systems, with limited exploration into the interconnected roles of ferroptosis and other mechanisms, such as mitochondrial quality control, neuroinflammation, and neurogenesis