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Practically, this means the peptides distribution and the coppers ultimate fate are dominated by whole-body copper homeostasis hepatic uptake, biliary excretion (the principal route by which the body eliminates excess copper), and the binding capacity of plasma proteins rather than by the peptide behaving as an independent, freely distributing drug

mRNA Extraction mRNA were extracted from cells using the RNeasy Mini Kit in accordance with the manufacturers instructions

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This library targets 18,205 human genes and contains 10 pools of 9570 GIPZ short hairpin RNAs (shRNAs) packaged into high-titer lentiviral particles