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They often deepen with age and become noticeable even at rest

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Roumeliotis S, Mallamaci F, Zoccali C (2020) Endothelial dysfunction in chronic kidney disease, from biology to clinical outcomes: a 2020 update

Complementary antioxidant supplementation (vitamin E, GSH, -carotene) effectively mitigates oxidative stress-induced lipid peroxidation, reducing isoprostane excretion and enhancing LDL oxidation resistance (Ciabattoni et al., 2000