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Increased phosphorylation of multiple intracellular kinases in the spinal cord, including c-Jun NH2-terminal kinase, extracellular signal-regulated kinase (ERK), protein kinase C (PKC), phosphatidylinositol-3 kinase, and p38-MAPK, is closely linked to the pathology of BIPN (Meregalli et al., 2014

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PMID 26816013

If you take valproic acid during pregnancy for any medical condition, your baby is at risk for serious birth defects that affect the brain and spinal cord and are called spina bifida or neural tube defects

In particular, clinical trials on human patients with depression, since, as we know, results from rodent models can't always be replicated in humans