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Moreover, chronic oxidative stress generated through CYP2E1 induction was shown to interfere with the insulin signaling cascade via a decrease in tyrosine phosphorylation of insulin receptor substrates 1 and 2

Another study showed that hydrogen-rich saline can upregulate the SIRT1/nuclear factor-B signaling pathway, thus reducing the shedding of vascular EG in S-AKI (139)