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Comment: One commenter requested that CMS consider the population of patients who may receive opioid antagonist and/or agonist medications for chronic pain management

Dual blockade immunotherapy targeting PD-1/PD-L1 and CTLA-4 in lung cancer

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[Ref] Cardiovascular Very common (10% or more): Sinus tachycardia (up to 23%) Frequency not reported : Increased heart rate In pooled placebo-controlled trials, treatment with this drug resulted in a mean increase in heart rate of 2 to 4 beats per minute compared to a mean increase of 1 beat per minute in placebo-treated patients