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The modification involves replacing the glutamic acid at position 3 with arginine (R3) , and extending the N-terminal region by 13 additional amino acids (MFPAMPLLSLFVN), resulting in a longer peptide chain of 83 amino acids compared to the native 70 in human IGF-1

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Importantly, these medications carry boxed warnings for medullary thyroid carcinoma risk and are contraindicated in patients with personal or family history of MEN2 or medullary thyroid carcinoma

[35] reported that excess accumulation of Cr significantly declines seed germination rate and plant growth which leads to plant biomass yield

Zhou Y, Hou Y, Shen J et al (2020) A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19