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HIIT naturally elevates MOTS-c levels and triggers AMPK activation, the same pathway that exogenous MOTS-c targets

But honest assessment requires acknowledging the evidence gaps that remain

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FOXO4 Forkhead box protein O4 is a protein that in humans is encoded by the FOXO4 gene

Consistent with this report, we find that NFS1 knockdown provides no survival benefit under cystine starvation in A549 cells and that ISCU knockdown exacerbates ferroptosis in these cells (Supplementary Fig