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Because it avoids hepatic first-pass metabolism, circulating citrulline is primarily cleared by the proximal renal tubule, where it is enzymatically converted to arginine

[DOI] [PubMed] [Google Scholar] [134].Scheppach W, Bartram P, Richter A, Richter F, Liepold H, Dusel G, et al

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While challenges persist in identifying unknown secondary metabolites, the evolving strategies for HRMS data collection and analysis provide optimism for unearthing therapeutic leads in the future (Peisl et al., 2018)

232 The deletion of S6K1 in mouse embryonic fibroblasts enhances mitochondrial fission by increasing both total DRP1 and its S616-phosphorylated form (not a target of S6K1 but a substrate of PINK1, CDK1 and other kinases), which in turn stimulates glycolysis