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39 In the study with 210,064 patients with diabetic peripheral neuropathy, patients taking gabapentin or pregabalin had a higher risk of cardiovascular events at five years compared with individuals not using either drug

Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats

These reactions can lead to the formation of free radicals, as the oxygen used in these metabolic processes to produce energy can give rise to the formation of free radicals or Reactive Oxygen Radicals (ROS)