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Description

Cell 91 , 443446 (1997)

In mammals, there are two functionally redundant ATG2 subtypes, ATG2A and ATG2B (Velikkakath et al, 2012)

A study with hyperlipidemic rats by Ahmed and co-investigators showed that dietary supplementation of black cumin seed extracts improved hyperlipidemic conditions by elevating high-density lipoproteins (HDL) level and lowering cholesterol, triglycerides, and low-density lipoproteins (LDL) levels [122]

In addition, Aldh2 / mice showed elevated hippocampal formaldehyde levels produced by mitochondrial sarcosine dehydrogenase and impairment in memory [32], suggesting that ALDH2 deficiency causes an accumulation of endogenous formaldehyde which may result in memory loss in mice