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doi: 10.1089/nat.2022.0009 85 HuYWenZLiuSCaiYGuoJXuYet al

10.1007/s00253-014-5616-8 6 ChaiL.LiJ.GuoL.ZhangS.ChenF.ZhuW.et al (2024)

(167) found that vitreous humor secretes Glia maturation factor- (GMFB) in a high-glucose environment, which in turn translocates the ATPase H + Transporting V1 Subunit A(ATP6V1A) from lysosomes, alkalizes lysosomes in RPE cells, and the ACSL4 protein ends up being digested in lysosomes, where an abnormal autophagy-lysosomal degradation process leads to the production of lipid species and ultimately induces ferroptosis in RPE

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Hormones play a role given its postpubertal and premenopausal pattern of onset