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At the same time, reduced IDO activity reduced kynurenine and further weakened peripheral immune tolerance, which played a driving role in the hypothyroidism immune disorder caused by the imbalance of the whole gut microbiota (Clarke et al., 2017)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Mohanty A., Bashir B., Kolekar K.A., Acharya A., Gulati M., Chaitanya M., Gupta M., Patle D., Gupta G., Singh S.K

Protection of midbrain dopaminergic neurons by the end-product of purine metabolism uric acid: potentiation by low-level depolarization

Together, these approaches create a comprehensive, medication-free plan for maintaining oral health and managing discomfort during pregnancy