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The reabsorption of these non-polar molecules and their return to the liver are referred to as enterohepatic circulation

Disruption of this homeostatic equilibrium can lead to dysbiosis and consequent metabolic perturbations that are increasingly implicated in the pathogenesis of chronic conditions such as cancer, cardiometabolic disorders, and IBD (187)

For example, the increased dosage of CBS and GCS in our simulation of Down syndrome causes the intracellular concentration of cysteine to decline while the blood concentration increases

MC level in drinking water was regulated to 10 mg/l per day for children

A better understanding of these dynamics may help optimize therapeutic strategies involving hyperbaric oxygen and antioxidant modulation in clinical practice