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[19] The enzymes that use B 12 as a built-in cofactor are methylmalonyl-CoA mutase (PDB 4REQ [43] ) and methionine synthase (PDB 1Q8J)

What Other Studies Say Aside from observational studies in humans, some animal studies have something to say about vitamin B-12 and its correlation with weight loss

Medication use, supplement overlap, neurologic symptoms, and baseline nutrient status should guide dosing

Fothergill, Amy, and Julia Finkelstein

Additionally, people with certain digestive disorders, such as Crohns disease or celiac disease, may struggle to absorb B12 from their diet and might require B12 injections to support digestive health