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For some, daily use may be fine, but others might need to limit it to avoid irritation or dryness. Using kojic acid soaps can result in potential side effects, such as contact dermatitis, a condition in which the skin becomes inflamed or irritated as a result of direct contact with a substance

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Scheffer DDL, Freitas FC, Aguiar AS Jr et al (2021) Impaired dopamine metabolism is linked to fatigability in mice and fatigue in Parkinsons disease patients

Similarly, severe heart failure or pulmonary edema represents a contraindication or strong precaution, as large amounts of glycine solution may expand intravascular volume and precipitate or worsen congestive heart failure or pulmonary congestion