interaction of chloroacetamide electrophiles with cellular glutathion Covalent inhibitors bacterial peptidoglycan biosynthesis enzyme MurA warhead Electrophilic compound screening identifies GPX4-dependent
Electrophilic compound screening identifies GPX4 dependent ferroptosis as a senescence vulnerability Nature Cell Biology Dual inhibition of carbonic anhydrase IX and glutathione peroxidase 4 as a novel strategy for ferroptosis induced tumor cell death ScienceDirect Glutathione Dynamics in Subcellular Compartments and Implications for Drug Development PMC NCBP1 stress signaling drives alternative S6K1 splicing inhibiting translation Nature Chemical Biology Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines Journal of Medicinal Chemistry
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