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Michael Rothman, a functional medicine specialist

318 The altered expression patterns of CLDNs can give rise to the development of gastric cancers

However, reduced enzyme activity should not be confused with an inability to utilise folic acid

Figure 2 Several studies in recent years have shown that silencing TRFC (the gene encoding TFR1) inhibits erastin-induced iron apoptosis and prevents LIP accumulation, whereas the heme oxygenase HO-1 increases intracellular free iron levels and promotes heme degradation, which speeds up the ferroptosis process (78, 79)