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Inclusion criteria Male and female individuals of at least 60 years of age at the time of the screening visit Diagnosis of mild cognitive impairment (31) or dementia (32) due to AD according to NIA-AA 2011 criteria Standardized mini-mental state examination score of at least 18 at the time of the screening visit Living in a community setting without continuous nursing care Can identify a reliable study partner with whom they have at least 3 weekly interactions to oversee study drug administration and participate in all clinic visits and some study procedures (including Cognitive Dementia Rating)

Red-flag symptoms such as severe abdominal pain, persistent vomiting, or jaundice require immediate cessation and urgent medical attention

Yang M, Gu K, Xu Q, Wen R, Li J, Zhou C, Zhao Y, Shi M, Weng Y, Guo B, Lei C, Sun Y, Wang H (2024) Recombinant Lactococcus lactis secreting FliC protein nanobodies for resistance against Salmonella enteritidis invasion in the intestinal tract

As a hepatoprotective agent, it is frequently prescribed as an adjuvant therapy along with other medications such as methotrexate, which has significant liver toxicity (Hussain and Marouf, 2013)

The large remaining fraction was allocated to ASCT2