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Though studies are ongoing, the implications on GPX4 are discussed below

It was only recognized in the late 1980s that desensitization of insulin secretion, which describes a state of decreased secretory responsiveness of -cell to the glucose stimuli, is a pathophysiological phenomenon of -cell function and not just an in vitro artifact 30

2006 Sep;92(1):119-31

Plates were preloaded with 10 l of laccase dilutions prepared in 20 mM citratephosphate buffer pH 7.0 as follows: 0.28 g ml 1 (LacAnc100) and 0.36 g ml 1 (LaccID) for ABTS, 1.4 g ml 1 (LacAnc100) and 1.8 g ml 1 (LaccID) for DMP, 3.4 g ml 1 (LacAnc100) and 4.0 g ml 1 (LaccID) for guaiacol, 1.7 g ml 1 (LacAnc100) and 8.1 g ml 1 (LaccID) for sinapic acid and 340 g ml 1 (LacAnc100) and 405 g ml 1 (LaccID) for p -coumaric acid

Mol Cell (2003) 12(4):8419