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Images were captured with Olympus FluoView FV3000 confocal microscope (Olympus Inc., Japan) under consistent conditions of acquisition to ensure comparable results

The fourth DMSO is bonded through oxygen

Currently, the related data about mechanism of anthraquinones-caused hepatotoxicity and nephrotoxicity is limited, which need further research

One of the RCTs found significant mean improvements in Clinical Global Impressions-Improvement (CGI-I) score and cellular methylation capacity, but not in the Aberrant Behaviour Checklist (ABC), Social Responsiveness Scale (SRS) or GSH metabolism, with those who had the lowest methionine status at baseline (suggesting impaired methylation capacity) significantly more likely to respond to supplementation