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Although metabolism-targeted therapy is not yet standard therapy for many cancers, several experimental and clinical trials targeting altered metabolism are currently underway

Leptin transport into the brain seems to be a limiting step in its central effects, but the way how blood leptin gains access to its target neurons in the brain is still an open question [60]

Moreover, the hyperpolarization also prevents post-synaptic transmission and thus the massive and deleterious entry of calcium

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