The FY 2026 Official Guidelines note that Chapter 11 (Diseases of the Digestive System) is reserved for future expansion
Common causes or triggers may include: Viral or bacterial infections including COVID-19, Lyme disease, Epstein-Barr virus (EBV), or pneumonia (5) Micronutrient deficiencies, including magnesium, vitamin D, and/or B vitamins (6) Existing autoimmune conditions including Hashimotos, Sjgrens, Celiac disease, or undiagnosed autoimmunity Mast cell activation, leading to histamine overload and systemic inflammation Connective tissue disorders including Ehlers-Danlos Syndrome (EDS) Toxin exposure including to mycotoxins from mold Chronic stress or unresolved trauma There are also different subtypes of POTS with different physiological causes: Neuropathic POTS: Caused by nerve dysfunction in the hands and feet (5,6) Hyperadrenergic POTS: Caused by too-high volumes of norepinephrine in the blood (5,7) Hypovolemic POTS: Caused by reduced blood volume (5) POTS and COVID-19 Does COVID cause POTS
doi: 10.2147/DDDT.S356307 55 LeishmanSAljadeedNMQianLCockcroftSBehmoarasJAnandPK
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