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In the first study, vacuolar protein sorting associated protein 4, which serves as an endolysosomal transport protein in other eukaryotes (Piper et al., 1994), was shown to be required for host cell cytosol uptake ( Concluding Remarks Until recently, many of the molecular players involved in nutrient uptake by Plasmodium parasites have remained elusive, largely due to the difficulties associated with genetic manipulation of the Plasmodium genome and studying the function of essential genes ( Plasmodium parasites

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