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Key insights from the review: Rapid growth of the field since 2019, led by the US, China, and Germany Strong focus on #stroke, #Alzheimers disease, #Parkinsons disease, and bioactive compounds from traditional Chinese medicine Identification of core molecular hubs: STAT3, IL6, TP53, AKT1, and JUN Major mechanistic hotspots include apoptosis, NLRP3 inflammasome, microglial polarization, and NF-B/JAK-STAT/PI3K-AKT pathways Why it matters The analysis highlights a paradigm shift away from one drugone target approaches toward multi-target, systems-level therapeutic strategies, better aligned with the multifactorial nature of neuroinflammatory CNS diseases

Works synergistically with Epithalons telomere-lengthening effects Resveratrol Activates sirtuins for DNA repair

The addition of KPV specifically expands KLOWs research scope to include anti-inflammatory and epithelial barrier studies

In: UpToDate, Connor RF (Ed), Wolters Kluwer

9 Table 1 summarizes common ATP7B mutations in different populations