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One of the most well-documented examples is ketoprofen gel , a topical NSAID commonly prescribed for localised musculoskeletal pain (Lodn 2004)

Whether glutamine availability is maintained by its exogenous supply or endogenously synthesised, this amino acid has unique metabolic and anti-inflammatory roles

Regarding mechanical components, tumor matrices are stiffer due to higher collagen production from stromal cells, and these collagen levels have been linked to Rho/ROCK and FAK regulation ( Unlike in the TME where angiogenesis is upregulated, some diseases are caused by or related to inhibited blood vessel growth, function, or survival

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Hu X, Fujimoto J, Ying L, Reuben A, Chen R, Chow CW, Canales JR, Sun W, Hu J, Parra Cuentas ER, Behrens C, Wu CJ, Swisher SG , Zhang J, Heymach J, Hong WK, Wistuba II, Futreal PA, Su D, Zhang J