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In a unilateral PD rat model, rats were subjected to either 1 or 4 weeks intermittent moderate treadmill exercise (Fernandes Ferreira et al., Another study using a rodent model showed that exposure to 6-hydroxydopamine (6-OHDA) led to a reduction of mitochondrial factors adenosine monophosphate (AMP)-activated protein kinase, PGC-1, and tyrosine hydroxylase (TH), and increased expression of silent information regulator T1, TFAM, and p53 (Rezaee et al., 2019)

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The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice

Kagawa S, Ji L, Xu K, McDonnell T, Swisher SG , Roth JA, Fang B