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doi: 10.1186/s12964-023-01413-9 26 CocozzaFMartin-JaularLLippensLDi CiccoAArribasYAAnsartNet al

As discussed below, despite being a small fraction of total intracellular GSH, mGSH plays a critical function in the maintenance of mitochondrial function and cell survival (Lash, 2006

This increase is observed in several diseases including congenital deficits in urea cycle enzymes, Reyes syndrome in children, uraemic encephalopathy, diabetic encephalopathy, or hypoglycaemic encephalopathy, although the most frequent cause for hyperammonaemia is associated with acute (due to poisons or drugs) and chronic (cirrhosis) liver failure