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2025;16:1582587.[DOI] 79

doi:10.1007/s40265-022-01717-z 7

CD4 + T cells, especially Th1 subsets, play a central role by secreting interferon-gamma (IFN-) to activate macrophages, while CD8 + T cells contribute through cytotoxic activity and cytokine production (Liu et al., 2025)