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An intramolecular disulfide bridge in the receptor-binding domain of the SARS-CoV-2 spike protein between Cys-488 and Cys-480, considered to be important for ACE2-binding, results directly inhibited by NAC and GSH and these compounds could be used effectively against SARS-CoV-2 cell viral entry and infection (Murae et al., 2022)

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In this disordered state, GSH may act as a flipper, disrupting protein interactions

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