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Hypomethylation of the epigenome and increased TET1 expression have been observed in colonocytes subjected to continuous iron exposure[113]

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This chronic inflammatory condition is generally not determined although genetics, copper, infectious agents, infections such as leptospirosis or viral infections, severe trauma and various drugs (phenobarbital, NSAIDs, paracetamol) may be implicated

A tale of two immune cells in rheumatoid arthritis: the crosstalk between macrophages and T cells in the synovium