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Vitamin B12 is required for creating new red blood cells

Wolf AJ, Reyes CN, Liang W, Becker C, Shimada K, Wheeler ML, et al

Given the established link between TLR4 and NLRP3 (96) as well as evidence from Gaucher Disease models (97), highlighting activation of the inflammasome, with subsequent caspase-1 activation, leads to the maturation of IL-1 in Gaucher macrophages and that inflammasome activation in these cells is the result of impaired autophagy