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Trimethyl chitosan-hyaluronic acid nano-polyplexes for intravitreal VEGFR-2 siRNA delivery: formulation and in vivo efficacy evaluation

Qi L, Lan B, Zhao Z, Ma Y, Song J, Jia Q, et al

Although the exact mechanism is still unclear, a mutation in bone morphogenetic protein type II receptors (BMPR2) inhibits the expression of the anti-apoptotic protein Bcl-XL and enhances apoptosis susceptibility in PAECs while promoting apoptosis tolerance by increasing the BcL-XL/BcL-Xs ratio through alternative splicing of the Bcl-x pre-mRNA in PASMCs [30, 31]