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This mechanism distinguishes 5-Amino-1MQ from NAD+ precursors (NMN, NR), which provide substrate for NAD+ synthesis

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Over-the-counter supplements typically contain 102,000 micrograms per dosefar exceeding physiological requirements

We refer to Supplementary Note 1 for more details on the cell-type dynamics and senescence in skeletal muscle

Nothing in this article should be interpreted as guidance for human use, in line with MHRA regulations under the Human Medicines Regulations 2012