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Le glutathion joue un rle complexe dans le contexte tumoral : s'il protge les cellules saines contre le stress oxydatif, des niveaux levs de GSH dans les cellules tumorales ont t associs dans certaines tudes prcliniques une rsistance accrue aux traitements

Xie PT, Hurley TD

It has also been demonstrated that these forms of glutathione cross the blood-brain barrier to actually decrease oxidative stress on brain cells

This correlated with efficient targets downregulation and a corresponding increase in GSH levels (Supplementary Figure S3A and B)

The precise pathological mechanism of HAPH remains elusive, with current research primarily focusing on pulmonary vasoconstriction and structural remodeling resulting from hypoxia