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(The term P450 refers to the 450-nm absorption peak characteristic of these heme proteins when they bind carbon monoxide.) The net result of a cytochrome P450-dependent oxidation reaction is: The reaction proceeds when the drug binds to the oxidized (Fe 3+ ) cytochrome P450 to form a complex, which is then reduced in two sequential oxidation/reduction steps as outlined in Figure 4-2A

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However, their dysfunction, marked by impaired oxidative phosphorylation, excessive oxygen species (ROS) production, and defective quality control, disrupts these processes and causes cellular and organ damage

doi:10.1002/bip.21416

Although there are differences in the suggested threshold for supplementing, ferritin can be used to test for iron deficiency