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ITF-2357 has advanced in multiple clinical trials, with recent progress in some indications

doi:10.1046/j.1365-2125.2001.01305.x

W., Weber, P., Quast, I

Daily exfoliation may lead to irritation or compromise the skin barrier, especially if the formula contains exfoliating acids

Even in the absence of overt overdose symptoms, therapeutic acetaminophen dosages can still increase the blood concentrations of liver enzymes (markers of liver damage) (Watkins 2006)