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Uric Acid Production as a Target of Therapy in Patients With Gout In the catabolism of purines, uric acid generation by the enzyme xanthine oxidase (that also has xanthine dehydrogenase activity) ( Figure 1 - 2 ) highlights the key therapeutic mechanisms of action of the xanthine oxidase inhibitors allopurinol and febuxostat ( Pharmacologic Urate-Lowering Therapy )

This entire process is called beta-oxidation, which is essential for ATP generation and fat oxidation, the primary source of energy for cells

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doi: 10.1038/s41591-019-0439-x

Ligaments are connective tissue outside the joint that link the bones