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In one aspect, this invention provides methods for improving the efficacy of genetic vaccines by providing materials that facilitate targeting of a genetic vaccine to a particular tissue or cell type of interest

EFCK3 ( Figure 2d ), 19 DEGs overlapped, and 10 upregulated ones except for TRINITY_DN4455_c0_g4 had higher expression levels on day 2, whereas nine DEGs were reversed in trend in both groups

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As part of this pathological process, hepatic lipid accumulation and immune cell infiltration trigger the sustained release of proinflammatory cytokines and chemokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-), driving a systemic inflammatory response [26, 29]

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