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The VcGST promoters contain numerous cis-elements associated with light response, stress response, and hormone signaling

Excessive sun exposure can cause the creation of melanin, which could potentially negate the effects of the injections

No other oral delivery mechanism achieves this

During de novo synthesis, L-serine is converted from 3-phosphoglycerate (3-PG), an intermediate of glycolysis, through a three-step enzymatic reaction, in which 3-phosphoglycerate dehydrogenase (PHGDH) is the first rate-limiting enzyme ( Figure 1a ) (Mattaini et al., 2016

Acknowledgements We thank Leo Kluijtmans, PhD, Clinical Laboratory Geneticist, Radboudumc, Nijmegen, the Netherland for critical review of Fig