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Since most early-onset point mutations are in this region (E46K, H50Q, G51D, A53T/V/E), it was deemed likely to be an important aggregation modulator and therefore a focal point for peptide aggregation inhibitor design

Dysfunction of SLC7A11 has been reported in diverse types of cancer, including PC, and is closely related to the malignant behavior of cancer [31, 32]

35 , 371 (2002) H

Hurst, R., Bao, Y., Jemth, P., Mannervik, B

Loss of LLF GGT activity in the mutant GGT enu1 mouse causes an increase in baseline LLF glutathione content which is magnified in an IL-13 model of allergic airway inflammation and protective against asthma