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The mechanism by which GB inhibited ferroptosis showed a strong correlation with Nrf2 activation, which was able to regulate the expression of several ferroptosis-related proteins, including FTH1, TFR1, HO1 and GPX4, thus promoting iron metabolism and repressing lipid peroxidation (133)

The 1,4-dimethylnaphthalene moieties in CP1-NCs can trap the 1 O 2 from 1,4-dimethylnaphthalene-functionalized Pt(II)-acetylide conjugated polymer (CP1) under NIR irradiation and form a stable endoperoxide