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Compound 3 (5.0 g, 6.20 mmol) was dissolved in 50 mL MeOH with NaOH (2 g, 50 mmol) under ice bath conditions

Eur J Endocrinol (2019) 181:K217

Many people with a deficiency describe deep fatigue, including an "afternoon crash." With infrequent dosing, blood levels can peak and then taper before the next visit

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Carcinogenesis, Mutagenesis, and Impairment of Fertility An 18-month study in mice with oral doses of ketorolac tromethamine tablets at 2 mg/kg/day (0.9 times the human systemic exposure at the recommended IM or IV dose of 30 mg qid, based on area-under-the-plasma-concentration curve [AUC]), and a 24-month study in rats at 5 mg/kg/day (0.5 times the human AUC) showed no evidence of tumorigenicity