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Downregulation of glyoxalase system does not result in MG accumulation Lower activity of the glyoxylate system through ROS deactivation and/or hypoxia-driven downregulation would be expected to lead to local MG accumulation in tumor tissue, especially since solid tumors are known to exhibit a high level of glycolytic dependency 56

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J R Stat Soc Ser B (Methodol)

Methods Diets, infection and dissection of the rats The animal experiments were approved by the animal welfare committee of Wageningen University (Wageningen, the Netherlands)

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