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Rather than simply co-administering two separate peptides, the team designed tirzepatide on the native GIP(1-42) backbone, then introduced specific amino acid substitutions at key positions to confer GLP-1 receptor cross-reactivity [6]

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This increase in IGF-1 is responsible for benefits such as neuroprotection, cell survival, and tissue regeneration, but GHRP-6 also acts directly to modulate immune responses, stimulate appetite, and influence other hormones and signalling pathways

The transcription factor Nrf2, as the master regulator of this response, represents a pivotal target

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