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The brain has a high level of metabolic activity and therefore cerebral tissues require an immediate and constant supply of oxygen

191 SonnenbichlerJ.ZetlI

In addition to succination, whose signalling is beyond the scope of this review and has been reviewed before [56], in the next sections, we will discuss the different signalling cascades triggered by FH loss and fumarate accumulation

They act through different mechanisms and may be complementary, not replacements

GO terms of muscle tissue development, myoblast fusion, and striated muscle cell differentiation were greatly enriched primarily due to the repression of rst