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The brain is highly dependent on oxidative metabolism

The phosphatidylcholine pathway plays a significant role in oxidative stress and inflammatory responses

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We recently reported that endothelial carnitine palmitoyltransferase 1a (Cpt1a) is reduced by hyperoxia, and that endothelial cell-specific Cpt1a knockout mice are more susceptible to developing hyperoxia-induced injury than wild type mice