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However, apparently contradictory results were observed in murine macrophages transfected with hmox1 shRNA

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nhr-49 is also required to induce non-lipid metabolism related genes, including the glyoxylate cycle enzyme gene icl-1 , the oxidoreductase gene sodh-1 , and the flavin-containing monooxygenase gene fmo-2 ( fmo-2 is required in wild-type worms for starvation survival ( nhr-49 is thus required for L1 stage starvation recovery in C

Most trials have reported good tolerability, with no serious adverse events observed during the intervention periods