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Variants in the intronic or flanking regions of the genes directly involved in the thiopurine pathway were correlated with unfavorable treatment response, but the functional impact of the variants was unclear (Matimba et al., 2014)

Nakashima, K

Gen Physiol Biophys 34:249261

Such events can cause cartilage to disappear, leading to long-term problems if not treated right

Based on the relevance of p53 in check-point signaling, such findings indicate that PER2 association with p53 might be a regulatory module that influences p53s downstream response to genotoxic stress