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7,8 Moreover, eating a healthy diet, such as the Dietary Approaches to Stop Hypertension (DASH) or Mediterranean diet, and lowering the intake of sodium, phosphorus and sometimes protein may help protect kidney function

Betaine is utilised in most tissues as an osmoproctectant in addition to its primary role as a methyl group donor in liver metabolism (reviewed by Zhao et al, 2018)

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2.3 Key bile acid-sensing receptors modulating the TIME 2.3.1 Farnesoid X receptor: transcriptional control linking metabolism and immunity in the TIME The farnesoid X receptor (FXR, encoded by NR1H4), a nuclear receptor superfamily member, is highly expressed in enterohepatic tissues and various immune cells (e.g., macrophages, DCs, T cells) ( Functionally, FXR-mediated transcription often promotes anti-inflammatory effects and supports immune homeostasis

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